The symbiotic world of colors
What was once only a vision of SF writers is slowly becoming a reality. In The Expanse novel series by James S. A. Corey, food production varies greatly depending on the location—Earth, Mars, the Belt, or the outer planets—and is influenced by technological and environmental factors. The goal is to produce food based on natural ingredients, using the possibilities offered by science to change their original purpose—fungi become juicy steaks, and algae turn into spaghetti.
It’s fascinating how science fiction’s imaginative food scenarios are increasingly reflected in modern food technology, especially concerning the use of fungi. Sci-fi literature frequently features food grown in controlled environments, such as space stations or urban farms. In addition to obtaining nutrients, the goal is also to make the food taste and look like what humanity is used to. The search for natural alternatives to synthetic food colorings has become a significant trend going beyond the boundaries of futuristic novels. Fungi can produce a range of pigments, offering potential for natural food coloring. While not as widespread as some other fungal food applications, research is ongoing into extracting and utilizing these pigments.
The basic idea of the BioExplor project, conducted by El Sayed Ramadan El Sayed, lies in the area of microbial biotechnology; using microbes as platforms for the production of valuable products. Among the microbial populations are endophytic fungi, which spend a part or whole lifecycle inside tissues of their host plant, typically without causing any obvious symptoms of disease. Forests in Poland are extensive and their biodiversity is high. Generally, forest trees are well known to live in close association with several microbial populations. These microorganisms (for example filamentous fungi) represent an untapped pool of novel bioactive compounds with potential applications in agriculture, medicine, and the food industry. Indeed, the large biodiversity of the yet unexplored fungal populations associated with these plants may be an infinite source of a wide range of bioactive compounds.

Filamentous fungi are a diverse group of microorganisms with long, thread-like structures called hyphae. They have traditionally been recognized for their role in the production of antibiotics, enzymes, and fermented foods. In recent years, they have gained attention as a source of natural food colorants, which are preferred over synthetic dyes due to health and environmental concerns. Their use in the food industry has a number of advantages.
Nowadays, consumers are increasingly seeking natural alternatives to synthetic food colors. In this aspect fungi produce a wide range of natural pigments, such as anthraquinones, naphthoquinones, azaphilones, and carotenoids. In addition, filamentous fungi can grow on inexpensive substrates, reducing production costs and environmental impact.
For two years, dr. El Sayed Ramadan El Sayed worked with a type of fungus called Monascus ruber SRZ112x, researching ways to improve the production of red pigment. He exposed the fungus to gamma rays, which helped create a unique or “mutant” version of the fungus which was capable of producing more pigment than the wild-type strain. To improve the results even more, the mutant strain was grown in an immobilized state, which means that its cells were fixed or trapped in a specific support material. This technique not only made the fungus more stable, but also allowed it to use nutrients more effectively, leading to better pigment production. His research also identified the optimal conditions – such as temperature, acidity, and nutrient concentrations – for maximizing the pigment output. By combining these two methods – exposing the fungus to gamma-rays and immobilized growth – the researchers were able to significantly increase red pigment production. This breakthrough could make the process more efficient and practical for large-scale industrial applications.
Thanks to the research project conducted by El Sayed Ramadan El Sayed,, we are witnessing the transformation of visions presented in SF books into our present lives.
Published papers: Enhancing bioprocessing of red pigment from immobilized culture of gamma rays mutant of the endophytic fungus Monascus ruber SRZ112 | Journal of Biological Engineering | Full Text
Novel nanoconjugates of metal oxides and natural red pigment from the endophyte Monascus ruber using solid-state fermentation | Microbial Cell Factories | Full Text
Principal Investigator: dr. El Sayed Ramadan El Sayed
Project Title: Unlocking Bioactivity of Forest Plants Associated Mycobiome as Sources of Novel Carotenoids and other BioPigments: Intensifying their Potential using Nanotechnology (BioExplor)